Role of proteinase-activated receptor-2 in allergic sensitization to house dust mite allergens
نویسندگان
چکیده
Background A number of common aeroallergens have serine proteinase activity, which is important for allergic sensitization. House dust mite (HDM), and other allergens with serine proteinase activity activate Protease-Activated Receptor-2 (PAR-2). We have shown that PAR-2 activation in the airways leads to allergic sensitization to concomitantly inhaled antigens, implicating PAR-2 in the pathogenesis of asthma. We hypothesized that PAR-2 activation in the airways by HDM allergens is important for the development of allergic sensitization.
منابع مشابه
Proteinase-activated receptor-2 promotes allergic sensitization to an inhaled antigen through a TNF-mediated pathway.
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